October 21, 2023
Uni-Padua-IT # PASTA - Phage Assisted Silencing Tool against Antimicrobial resistance # Antimicrobial resistance (AMR) poses a critical global public health threat, with increasing mortality rates and substantial economic implications. Italy, notably affected, faces approximately 11,000 deaths attributed to AMR infections annually. A group of pathogens, collectively known as ESKAPE(E), including bacteria like Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa (and Escherichia coli), contribute significantly to this crisis. WHO recognizes the urgency of research and development for antimicrobials and diagnostics.
...
October 21, 2023
UOregon # HGT: Hostile Gene Transfer # We are developing an E. coli Nissile 1917 (EcN) based therapeutic to selectively target and destroy GI tract pathogens. It is a precise, modular, alternative to small-molecule antibiotics. Our first target is Helicobacter pylori, a stomach pathogen infecting more than 50% of humans. We bind to surface proteins present on our target and conjugate a malicious DNA payload into our target cell. We’ve engineered our strain to survive in the stomach by upregulating the glutamate-dependent acid resistance using GadE (BBa_K1639002).
...
October 21, 2023
UZurich # LactoBack # Endometriosis is an underresearched and underdiagnosed disease characterized by growth of endometrial cells outside of the uterus. Recent research points towards a link between inflammation in the endometrium and dysbiosis of the vaginal microbiome. The mission of project “LactoBack” is, in light of recent discoveries, to implement a microbiome-targeted treatment of vaginal dysbiosis and endometriosis. To raise awareness of endometriosis and microbiome health, talks with professionals in women’s health and surveys of patients were organized.
...
October 21, 2023
Virginia # NiSkin: A Transdermal Antibiotic Delivery System for Cellulitis Treatment # Annually, over 14 million cellulitis cases occur in the United States, totaling over $3.7 billion in ambulatory costs. Cellulitis is a common skin infection that occurs in the dermis. Oral and intravenous antibiotics are the standard treatment, because the upper skin layers serve as formidable barriers, rendering it difficult for topical treatments to reach the dermis. Instead, antibiotics travel through the circulatory system, leading to unfavorable interactions with the body’s microbiome, causing patient discomfort and promoting antibiotic resistance.
...
October 21, 2023
ZJUintl-China # Cancer Sniper: A new Lung Cancer Therapy # The Cancer Sniper is a new cancer Therapy based on engineered bacteria. We found a bacteria suitable for survival and secretion of anti-tumor factors in the lung cancer microenvironment by machine learning. Then we used 3 input AND gate which can simulate tumor microenvironment to trigger the expression of anti-tumor factor CDD-iRGD.We detected the expression of the anti-tumor factor and the anti-tumor efficiency of the bacteria.
...