October 21, 2023
SYSU-SLS-CHINA # SYN-MACRO (Synthetic engineering macrophage for Hepatocellular Carcinoma therapy) # Cancer is a malignant disease that poses significant threats to human health. In recent years, immunotherapy approaches such as CAR-T have emerged promising for cancer treatments. However, CAR-T has demonstrated limited effectiveness in treating solid tumors. The use of CAR-M therapy also presents certain limitations. Macrophages exhibit M1/M2 phenotypes. While macrophages in solid tumor are often being “domesticated” into the M2 phenotype.
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October 21, 2023
Technion-Israel # UTBye – Treating recurrent urinary tract infection using genetically modified Lactobacillus Crispatus # Recurrent Urinary Tract Infections (UTIs), predominantly affecting women, pose a significant health concern. Current treatments rely on antibiotics, leading to resistance and questionable efficacy. In response, our iGEM project explores the under-researched realm of recurrent UTI treatment. We’ve identified the microbiome’s pivotal role in maintaining urinary tract balance, highlighting Lactobacillus crispatus as a key player.
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October 21, 2023
Thrace # Depregut # Modern populations are increasingly overfed, malnourished, sedentary, sunlight-deficient, sleep-deprived, and socially-isolated.This seems to come with an impact for both their physical and mental health. Available research data tend to accuse modern environments of causing an epidemic of depression.
現代の人口は、増えすぎた食事、栄養不足、運動不足、日光不足、睡眠不足、社会的孤立が増えています。これには彼らの身体的及び精神的健康に影響を及ぼすようです。利用可能な研究データは、現代の環境がうつ病の大流行の原因とする傾向があります。
reference:
iGEM Thrace Team Information iGEM Thrace Wiki
October 21, 2023
Toulouse-INSA-UPS # CALIPSO: the rise of smart liposomes in cancer treatment # Our team iGEM Toulouse tackles the challenge of side effects in cancer treatment with CALIPSO, an intelligent therapeutic liposome. It senses cancer biomarkers, produces the anticancer drug in situ, and delivers it right on the tumor site. By combining in silico protein design, genetic biosensors, cell-free protein synthesis, and biochemical network modeling, we devised an integrated liposomal platform with cell-like functionalities to specifically kill cancer cells.
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October 21, 2023
Tsinghua # TabcT: Thermal Activated Bacteria Cancer Therapy # TabcT (Thermal Activated Bacteria Cancer Therapy) is a temperature-controlled bacterial therapy developed by Tsinghua 2023, targeting breast cancer, and it offers the advantages of being cheap, convenient, controlled, continuous, and comprehensive. ECN, a probiotic is genetically modified and injected directly into the tumor. These bacteria cannot survive in aerobic healthy human tissue but colonize within the anaerobic tumor tissue. To precisely target and work, an AND gate is used.
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October 21, 2023
TU-Eindhoven # cELPro for non-invasive, affordable treatment of IBD # Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal tract that affects 4.9 million people worldwide. Current treatments aim at relieving the symptoms of the disease. However, those are not specific enough, cause many side effects or are very expensive. The TU-Eindhoven team wants to tackle this challenge by developing an affordable, safe, targeted microbe-based therapy that works locally in the bowel.
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October 21, 2023
Tuebingen # To build a blood type - from B to A # Blood donation shortages are a pressing concern for health facilities worldwide. Additionally, the availability of blood donations is further limited by the incompatibility of blood types. Among the four canonical types, only group O is universally suitable for donation due to the absence of blood antigens on the surface of red blood cells.
全世界の健康施設で、血液供給の不足は深刻な問題となっています。さらに、血液型の非互換性により、血液の提供がさらに限定されています。四つの典型的な型の中で、赤血球の表面に血液抗原の欠如があるため、グループOだけが普遍的に寄付に適しています。
reference:
iGEM Tuebingen Team Information iGEM Tuebingen Wiki
October 21, 2023
UI-Indonesia # Effectivity of Modified Salmonella Typhimurium A1-R Strain Secreting Buforin IIb in Eradicating Cervical Cancer # As cervical cancer presents threat toward women across the globe, treatment is crucial to suppress the impact. However, as most disease is discovered at advanced stage due to the low rate of early detection, the current treatment can only repress and perhaps even temporarily obliterate cervical cancer. The current treatment employed might not be able to ensure full remission and proper quality of life ahead.
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October 21, 2023
ULaval # Blood Cell Barber Shop: An enzymatic treatment for universal blood donations # Blood donations are critically needed to help patients suffering from various illnesses or accidents. Blood banks face persistent supply challenges for specific blood types needed by vulnerable patients.
様々な病気や事故で苦しんでいる患者さんを助けるために、血液の提供は非常に重要です。血液銀行は、特定の血液型が必要とされる弱い患者さんに対して、常に供給の問題に直面しています。
reference:
iGEM ULaval Team Information iGEM ULaval Wiki
October 21, 2023
UM-Macau # GEIG: Gluten Enzymatic Intestinal Guardians # Celiac Disease (CD) is the worldwide autoimmune gluten intolerance disease. Current treatments include lifelong gluten-free diets and oral enzyme therapy, but these therapies bring inconvenience to patients’ lives and the latter is still immature. UM-Macau aims to establish a rapid and targeted delivery and adhesion system that releases prolyl endopeptidases through probiotics under the control of NO sensors, as an alleviator of inflammatory-like environmental factors in CD intestine.
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