October 21, 2023
McMasterU # HelmiGuard: Using Phage-Based Technology to Fight Neglected Diseases # Everyone deserves to be healthy, but not everyone has that privilege. Billions of people from poverty-stricken regions suffer from Neglected Tropical Diseases (NTDs), caused by pathogens found in their communities. At HelmiGuard, we have created an oral vaccine to help forge a path to hope for two of the deadliest NTDs: echinococcosis & cysticercosis. Using adeno-associate virus phage (AAVP) technology - a filamentous bacteriophage modified to interact with human cells - we hope to target and destruct the larvae in the small intestine, before they can grow and spread.
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October 21, 2023
MIT # CAR-P Diem: Seize the day! # Cancer cachexia is a severe muscle and fat wasting disease which directly causes 30% of cancer-related deaths, yet it is strikingly understudied. No treatments exist beyond exercise and diet regimens in the United States. The MIT iGEM team proposes CAR-P Diem: a therapy using macrophages equipped with a chimeric antigen receptor that specifically recognizes and phagocytoses interleukin 6 (IL-6) via an extracellular anti-IL6 antibody.
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October 21, 2023
Munich # BEE: B-cell engineering & enhancement # Our project focuses on a novel synthetic biology concept of B-cell engineering. We are genetically engineering B-cells to produce a specific antibody with the aim of using these cells as living and evolving drugs in cell therapy. Our goal is to address the epidemic of neurodegenerative diseases, particularly Alzheimer’s, to protect high-risk patients from multi-resistant pathogens, to tackle chronic viral diseases, such as MRSA and hepatitis B virus, and to combat malignant tumors, such as renal cell carcinoma.
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October 21, 2023
Nantes # – Not provided yet – # – No abstract provided yet –
– まだ要約は提供されていません –
reference:
iGEM Nantes Team Information iGEM Nantes Wiki
October 21, 2023
NCSU # Project Forget-Me-Not: A comprehensive study of Alzheimer’s disease # Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder affecting over 55 million people worldwide. Currently no effective treatments exist to halt or reverse AD progression. This project develops a novel biotherapeutic to delay AD onset by engineering the probiotic bacterium Clostridium butyricum to produce the neuroprotective metabolite butyrate. Using a two-plasmid CRISPR/Cas9 gene editing system delivered via bacterial spores to the gut, C.
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October 21, 2023
NJMU-China # Breaking the silence of the deep sea: One encounter at 52Hz frequency # Autism spectrum disorder (ASD) is a common neurodevelopmental disorder, and its incidence is increasing in recent years, which brings great burden to social development and medical security. It has been reported that due to genetic and environmental factors, the increased autoimmune antibodies in the brain of ASD patients will attack neurons, resulting in neuron death and disorder of behavior.
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October 21, 2023
NMU-China # Gut-Sweeper: an engineered E. coli that integrates prevention, monitoring and treatment of constipation # Functional constipation is prevalent among the elderly, which gains an increasing concern as the population ages. In keeping with our view of “local people solve local problems”, we have designed our Gut-Sweeper, namely, an engineered E. coli that integrates prevention, monitoring, and treatment of constipation. We firstly empowered our engineered bacteria with monitoring ability by the butyrate sensory module, which can detect a distinct lowered butyrate concentration, a research-proven constipation marker.
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October 21, 2023
NU-Kazakhstan # Living bacteria-mediated carcinoma tumor therapy # Cancer remains one of the deadliest diseases in the world despite the advances in current diagnosis and treatments. Current challenges in onco-therapy include targeting, specificity, and side effects. With that in mind, we are focused on applying synthetic biology to develop a live bacteria-based antitumor therapeutic vaccine delivered in situ to solid carcinomas by a thermosensitive hydrogel. We will use a non-pathogenic strain of E.
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October 21, 2023
NUDT-CHINA # ARROR: a PVC-Based delivery of UCP1 into adipose tissue for efficient body weight control # In the past 50 years, significant progress has been made in managing diseases closely linked to excess body weight. However, treating obesity itself has been challenging, with medications often providing inadequate efficacy and potential safety concerns. Here, we demonstrate a novel synthetic biology-inspired therapeutic nanomachine to reduce excess body fat by effectively delivering Uncoupling protein 1 (UCP1) into white adipose cells.
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October 21, 2023
NWU-CHINA-A # Super Probiotics: Intestinal Knight Engineered Bacteria Beat IBD # Our project focuses on the treatment of Inflammatory Bowel Diseases ( IBD ) by constructing engineered probiotics . The concentration of reactive oxygen species ( ROS ) is an important factor in the occurrence and development of IBD . We plan to express Catalase ( CAT ) , superoxide dismutase ( SOD ) and Elafin ( an endogenous human protein that inhibits neutrophil-derived serine proteases elastase and protease-3 ) in probiotics Escherichia coli Nissle 1917 .
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