October 21, 2023
HZAU-China # C.A.T: Cat Allergic Therapy # Feline allergies are a common source of allergens, affecting up to 15% of adults and children and causing symptoms from allergic rhinitis to severe asthma. Feline allergens, Fel d1 (Felis domesticus allergen 1), are mainly produced by the salivary glands, and when cats groom themselves, Fel d1 is transferred from saliva to their hair, and cat dander containing Fel d 1 allergen is then spread to the environment as small airborne particles.
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October 21, 2023
IISc-Bengaluru # MetraMorpheus, our attempt to treat Endometriosis non-invasively, using the power of mRNA! # We propose a unique, immunotherapeutic strategy to combat endometriosis. Largely, we aim to produce the antibody O-1L8-15 to block Interleukin-8 (CXCL8), a chemokine advancing endometriosis. A previous study used monoclonal antibodies to block IL8, reducing endometriotic tissue volume in monkey models. Our goal is to specifically target the peritoneal concentration of IL-8, using biochemistry and microfluidics to attach an aptide to an LNP, enhancing disease specificity.
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October 21, 2023
IISER-Tirupati-India # AnthraFelix: Novel probiotic therapeutic for Irritable Bowel Syndrome-Diarrhoea Predominant(IBS-D). # IBS-D is a prevalent Functional Gastro-Intestinal Disorder (FGID), affecting approximately 11.2% of the global population and 7.5% of Indians. Stress, unhealthy diet, disrupted gut microbiota, and genetic factors contribute to this syndrome. The rise of urbanization and globalization in developing nations has significantly impacted lifestyle, resulting in disturbed sleep, altered diet patterns, and adverse health effects. IBS-D symptoms include diarrhoea, bloating, disturbed sleep, and nausea.
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October 21, 2023
IITChicago # – Not provided yet – # – No abstract provided yet –
– まだ抄録が提供されていません –
reference:
iGEM IITChicago Team Information iGEM IITChicago Wiki
October 21, 2023
INSAENSLyon1 # SUPERBUGBUSTER, a removal of antibiotic resistance # Called the “silent” pandemic, antibiotic resistance is one of the most important issues that contemporary medicine faces today. Causing millions of deaths per year all over the world, the number keeps rising to a predicted 10 million deaths in 2050. It is mainly due to our over-consumptions through the years. But for now, no technological solution exists, and no new antibiotics have yet been discovered.
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October 21, 2023
IOANNINA # IRIS: A novel cancer therapeutic approach combining Photodynamic Therapy and Bacteria Mediated Tumor Therapy # Addressing the global burden of cancer, and especially solid tumors, which account for approximately 90% of cancer cases worldwide, we propose IRIS: Unleashing the light within. IRIS is a novel therapeutic approach merging Photodynamic Therapy and Bacterial Mediated Tumor Therapy, two promising methods employed in the battle against cancer. By utilizing E.coli, a facultative anaerobic bacteria species, we specifically target the nutrient-rich hypoxic regions of solid tumors and express the necessary genes for an efficient therapy.
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October 21, 2023
Jilin-China # Mela-no-more —-Innovative Bacterial Therapy for Targeted Treatment # Melanoma, characterized by its aggressive nature, high incidence, and tendency for metastasis, results in significant cases and deaths on a global basis. The current therapeutic methods suffer from problems such as poor efficacy and strong side effects year, highlighting an urgent need to alternative treatment. This year Jilin-China aims to achieve regulated and precise treatment of melanoma. E.coli Nissle1917, a kind of non-pathogenic bacteria is selected and equipped with three systems: the regulatory system controlling the expression of engineered bacteria, and therapeutic genes carefully screened to achieve effective treatment, with Toxin-Antitoxin system ensuring bio-safety.
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October 21, 2023
JLU-China # EyeGuard: A System for Inhibiting Pseudomonas aeruginosa Using DMBT1 Protein Generation and Hardware Platform # Contact lenses, while correcting vision and enhancing aesthetics, pose hygiene risks, including Pseudomonas aeruginosa infection. Our iGEM project addresses this by engineering E. coli into lens solutions, creating a DMBT1 protein system to inhibit Pseudomonas growth, reducing infection risks. This system comprises a toxin-antitoxin system, population sensing system for bacterial growth control, and an Hsp27 self-inducing system for increased protein production.
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October 21, 2023
JLU-NBBMS # Salmonella-based Colorectal Cancer Innovative therapy # Treatment measures for colorectal cancer usually include endoscopic resection, radiotherapy, drug therapy, etc., but the treatment of a specific treatment alone is not good. Based on the above background, the JLU-NBBMS team adheres to synthetic biology and tries to use engineering-modified bacteria to treat solid tumors. We plan to treat colorectal cancer using attenuated salmonella carrying small nucleic acid drugs. The attenuated salmonella can take small nucleic acid drugs, accurately target cancer tissue, and quickly enrich them.
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October 21, 2023
McGill # Proteus - A programmable and modular oncogene targeting and pyroptosis inducing system # Prevalence of cancer has been on the rise in the last twenty years, with cancers like pancreatic cancer still not improving in terms of treatment options. We engineered a novel, personalized therapeutic technique. A personalized treatment modality restricts negative off-target effects, ideally killing cancerous cells before surgical resection becomes the only viable treatment. We utilize the newly discovered CRISPR system, Craspase, to engineer forced pyroptotic cell death among cancerous cells.
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