October 21, 2023
EPFL # 48C: Developing a Live Biotherapeutic Product for Cadmium Intoxication # Cadmium, a highly toxic heavy metal, poses a severe threat to public health and the environment. Classified as a group-one carcinogen by the International Agency for Cancer, cadmium contamination remains a critical issue. It accumulates in soil and water, impacting food supplies.
カドミウムは、非常に有害な重金属であり、公衆衛生と環境に深刻な脅威をもたらしています。国際がん研究機関により、グループ1の発がん物質として分類されているカドミウム汚染は未だに重要な問題です。これは土壌や水に蓄積され、食物供給に影響を及ぼします。
reference:
iGEM EPFL Team Information iGEM EPFL Wiki
October 21, 2023
Evry-Paris-Saclay # OptoGenEYEsis # Imagine a world without sight - a harsh reality for many.
視覚がない世界を想像してみてください - 多くの人々にとってこれは厳しい現実です。
reference:
iGEM Evry-Paris-Saclay Team Information iGEM Evry-Paris-Saclay Wiki
October 21, 2023
Exeter # CathExe - Preventing biofilm formation on urinary catheters. # In the National Health Service (NHS) 1 in 5 hospital patients are catheterised, with this increasing to 70% in critical care units. Catheter usage is the predominant risk factor for 70-80% of urinary tract infections (UTIs) - these are referred to as catheter-associated UTIs (CAUTIs).
国立保健サービス(NHS)では、5人に1人の入院患者がカテーテルを使用し、これが集中治療室では70％に増加しています。カテーテルの使用は、尿路感染症(UTI)の70〜80％の主要なリスク要因で、これらはカテーテル関連尿路感染症(CAUTI)と呼ばれています。
reference:
iGEM Exeter Team Information iGEM Exeter Wiki
October 21, 2023
FSU # – Not provided yet – # – No abstract provided yet –
– まだ抄録が提供されていません –
reference:
iGEM FSU Team Information iGEM FSU Wiki
October 21, 2023
Guangxi-U-China # Engineered Bacteria with Nano-Immunomodulator for Precision Therapy of Triple Negative Breast Cancer # Triple negative breast cancer is the most aggressive subtype with poor prognosis and high risk of recurrence. The treatment is challenging because of limited chemotherapy responses, lack of actionable targets and acquired resistance to immune checkpoint inhibitors-based therapies. In particular, the acidic and hypoxic microenvironment caused by the high glycolytic activity of tumor cells promotes the non-inflammatory polarization of tumor-associated macrophages.
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October 21, 2023
HainanU-China # Inflammation fighter # At present, acne is one of the most common skin diseases in the world, affecting the lives of the general people, among which adolescence is the highest age group of acne. Adolescence is a very special stage of life, when students often feel upset and tired from skin problems caused by physical changes and hormonal production. With the increase of skin problems such as acne, adolescent adolescents often feel frustrated and low self-esteem, which brings great difficulties in their learning and social interaction.
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October 21, 2023
Hamburg # transFERRITIN - because we want to transfer it in! # Multiresistant pathogens are a rapidly emerging threat in our modern world. The World Health Organisation projects that by 2050, antibiotic resistances claim up to 10 million lives annually. A driving force behind antibiotic resistances is the overuse and inappropriate application of antibiotics.
多耐性病原体は、現代の世界で急速に増加している脅威です。世界保健機関は2050年までに、抗生物質耐性が年間最大1千万人の命を奪うと予測しています。抗生物質耐性の背後にある推進力は、抗生物質の過度な使用と不適切な適用です。
reference:
iGEM Hamburg Team Information iGEM Hamburg Wiki
October 21, 2023
HiZJU-China # Biolens # Our project is dedicated to the prevention of myopia. The name of our project is biolens. We plan to load the modified engineered bacteria with contact lenses. The modified engineered bacteria can produce salidroside under the condition of elevated intraocular pressure, which is a biological antioxidant and has the function of preventing myopia. In addition, we designed the engineered bacteria to be coated with liposomal vesicles embedded with specific transporters to prevent metabolic waste from being excreted and allow only salidroside to pass through.
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October 21, 2023
HKPOLYU # An innovative approach to construct a bispecific antibody to combat the Osimertinib resistance in NSCLC # Our project addresses the critical issue of Osimertinib resistance in non-small cell lung carcinoma (NSCLC). NSCLC accounts for 85% of all lung cancer cases and the average five-year survival rate is only 28%. Apart from common treatments such as surgery, chemotherapy, and checkpoint inhibitors, Osimertinib, as the first-line targeted therapy for NSCLC patients with an EGFR mutation, can develop acquired drug resistance, thus affecting its long-term efficacy.
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October 21, 2023
HKU-HongKong # Car-Ma # Immunotherapy has been gaining popularity, and examples like CAR-T have been proven efficient in treating liquid cancer. However, in solid tumours, the tumour microenvironment (TME) acts as a physical barrier and prevents phagocytosis. Moreover, M2-like phenotype tumour-associated macrophages (TAMs) in TME would promote tumour growth. Our lab is working on delivering the CAR transgene into the tumour-associated macrophages that target hepatocellular carcinoma. First, we will be knocking out SIRP-alpha through the use of Cas9 gene editing, which enhances phagocytosis.
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