October 21, 2023
AFCM-Egypt # A therapeutic approach for Rheumatoid Arthritis using Mesenchymal Stem Cells for tissue-specific exosomal mRNA delivery # Our team has developed a novel therapeutic platform for Rheumatoid Arthritis (RA), which is an autoimmune condition that mainly targets synovial joints, resulting in prominent joint inflammation. Conventional treatments for RA can have dangerous side effects, especially with long-term use. Introducing our SUPER-Cell, which consist of mesenchymal stem cells that have been engineered to express a Syn-Notch receptor.
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October 21, 2023
Bielefeld-CeBiTec # ASTERISK - Advanced Sequencing of Tumor markers Enabling mRNA-based Intraoperative Sensing and Killing # Cancer persists as one of the deadliest diseases of all time. The survival rate of patients with glioma, a type of brain cancer, is extremely low and intraoperative diagnostics is considered to be one of the key factors in increasing patients’ chances. Our project ASTERISK combines intraoperative diagnostics via Nanopore sequencing with mRNA treatment.
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October 21, 2023
BilkenTR-UNAM # Revolutionizing SMA Therapy: A Self-Amplifying RNA Platform for Innovative Treatment # Our iGEM 2023 initiative targets the pressing challenges of Spinal Muscular Atrophy (SMA), a debilitating condition causing muscle weakness and atrophy. With our nation’s SMA prevalence twice the global average, the economic strain of current treatments necessitates new solutions.
当社のiGEM 2023のイニシアチブは、筋力の弱化と萎縮を引き起こす重大な病状である脊髄性筋萎縮症（SMA）の喫緊の課題を対象にしています。我が国のSMAの有病率は世界平均の2倍であり、現行の治療法の経済的な負担は新たな解決策を必要としています。
reference:
iGEM BilkenTR-UNAM Team Information iGEM BilkenTR-UNAM Wiki
October 21, 2023
BITSPilani-Goa-India # Project CARKinos - a better way to treat Lung Cancer # Non-small cell lung cancer (NSCLC) accounts for 82% of all cancer cases in India and has an extremely poor prognosis. A characteristic specific to solid tumors is Antigen-Heterogeneity on the surface. This property neutralizes antigen-specific treatments, like Chimeric Antigen Receptor (CAR) - T therapy. To mitigate this problem, we propose a treatment which targets the adhesion mechanism of the tumor and disintegrates it.
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October 21, 2023
BNUZH-China # FeFighterS – Engineered Bacteria Induce Ferroptosis in Tumor Cells # In this project, we have developed a novel strategy that utilizes attenuated Salmonella typhimurium VNP20009 to induce ferroptosis in tumor cells. To further enhance the tumor targeting ability, we had genetically modified VNP20009 to express single chain antibody fragments on the outer membrane. Once the engineered bacteria reached the tumor tissue, it will secrete glucose oxidase into the tumor cells, mediating the occurrence of the Fenton reaction.
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October 21, 2023
BUCT # NephroWiz # BUCT focuses on helping many patients with chronic kidney disease (CKD), and it is our team’s top priority to help them alleviate the pain and improve the quality of life. We sincerely hope to provide them with effective help! We take the genetically engineered E. coli nissle 1917 as the carrier, hoping to reduce the content of creatinine and urea in patients through intestinal exudation in the form of probiotics, and generate non-toxic polyglutamic acid and the nutrient sarcosine.
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October 21, 2023
Calgary # CholesterLock # iGEM Calgary presents CholesterLock, a novel proof of concept for an alternative high cholesterol medication. It employs synthetic biology to develop a fusion protein that targets NPC1L1, a lipid transporter protein found in the lining of the small intestines. NPC1L1 is involved in absorption of both cholesterol, and saturated fats which are used in the downstream synthesis of cholesterol. Our fusion protein consists of an Immunoglobulin G fragment, a linker, and a hedgehog family protein fragment bound to cholesterol, which is meant to inhibit NPC1L1 by blocking the site of cholesterol intake, preventing absorption.
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October 21, 2023
CPU-CHINA # BI-BYE: Solution of Engineering Probiotics for Colorectal Cancer # Colorectal cancer (CRC) ranks as the third most common cancer worldwide.However, the treatment options for CRC are often expensive and have limited efficacy, causing severe adverse effects among patients.So there is an urgent need for improved treatment options for colorectal cancer.Fusobacterium nucleatum (Fn) is closely linked to the onset and progression of CRC, resulting in unfavorable prognoses.This year, CPU-CHINA has devised a therapy for Fn-mediated CRC.
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October 21, 2023
CSU-CHINA # Design a cell to secret GnRH in a pulsatile fashion # GnRH is a hypothalamic decapeptide produced and secreted by the hypothalamus in a pulsatile fashion. The most important role of GnRH is to maintain the activity of the HPG axis and stimulate the development of sexual organs.
GnRHは、視床下部が脈動的に生成し分泌するデカペプチドです。GnRHの最も重要な役割は、HPG軸の活動を維持し、性器の発達を刺激することです。
reference:
iGEM CSU-CHINA Team Information iGEM CSU-CHINA Wiki
October 21, 2023
Duke # ICARUS - Intelligent Chimeric Antigen Upregulation System # Chimeric antigen receptor (CAR) T-cell therapy has shown great promise in treating certain hematologic cancers by reprogramming patient T-cells to target tumor antigens. However, application of this therapy to solid tumors has been limited by issues such as heterogeneity of antigen expression, tumor inaccessibility, and immunosuppressive tumor microenvironments. Our project describes an integrated CAR-synNotch circuit, the Intelligent Chimeric Antigen Receptor Upregulation System (ICARUS), to address these limitations.
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