October 21, 2023
Bangkok-NMH # Personalized Neoantigen Prediction Algorithm for DC Vaccine Cancer Treatment # Our collaborative project with Chulalongkorn University Hospital addresses the challenge of identifying DNA sequences for T-cells and neoantigens in dendritic cell (DC) vaccine development. Our workflow, guided by Sprint Planning, encompasses patient sample analysis, sequence alignment, HLA typing, and variant calling for tumor-specific peptides. Our product consists of using FastAPI, Mongo Atlas, and React through Amazon Web Service (AWS) deployment.
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October 21, 2023
MunichBioinformatics # SEPiA - Side-Effects and Polypharmacy interaction Ai # Polypharmacy is the simultaneous use of more than five medications. While often necessary for treating multimorbid patients, polypharmacy is associated with a decline in the patient’s health outcomes.
ポリファーマシーとは、5つ以上の薬を同時に使用することを指します。多疾患の患者を治療するためにはしばしば必要ですが、ポリファーマシーは患者の健康状態の低下と関連しています。
reference:
iGEM MunichBioinformatics Team Information iGEM MunichBioinformatics Wiki
October 21, 2023
SJTU-software # Directed Ago Renewal With Ideal proteiN thermal-Stability (DARWINS) # COVID-19 has caused a large number of deaths worldwide, regardless of each country’s economic situation. and has served as a stark reminder of the paramount importance of precise and rapid disease detection.
COVID-19は、各国の経済状況に関係なく、世界中で大量の死者を引き起こし、正確で迅速な疾病の検出の極めて重要性を如実に示しています。
reference:
iGEM SJTU-software Team Information iGEM SJTU-software Wiki
October 21, 2023
SYSU-Software # BioRocket: Systematic Discovery of Novel Protein Delivery Systems in Massive Prokaryotic Genomes # Prokaryotes have evolved various protein delivery systems that enable these organisms to interface with host cells. One example, the extracellular Contractile Injection Systems (eCISs) are syringe-like protein complexes that can inject proteins into host cells. Despite the potential as programmable protein delivery tools, only a few eCISs have been characterized. Here, we designed the BioRocket platform to systematically mine eCISs from prokaryotic genomes using machine learning and structure-based protein alignment methods.
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October 21, 2023
Tongji-Software # CASleuth——the virus detective agency # We have developed a cutting-edge gRNA design tool——CASleuth. It is specifically designed for CRISPR virus detection. This tool aims to recommend highly efficient gRNAs that can accurately detect the target virus. Moreover, the recommended gRNAs are seamlessly integrated into the comprehensive database we have constructed.
私たちは最先端のgRNA設計ツール——CASleuthを開発しました。これは特にCRISPRウイルス検出のために設計されています。このツールは、目標のウイルスを正確に検出できる効率的なgRNAsを推奨することを目指しています。さらに、推奨されるgRNAsは、私たちが構築した包括的なデータベースにシームレスに統合されています。
reference:
iGEM Tongji-Software Team Information iGEM Tongji-Software Wiki
October 21, 2023
Tsinghua-A # Multi-Species Automatic Antibody Drug Design System # Antibody drugs, with their better specificity and lower side effects, account for a large proportion of newly approved human drugs. However, the development of drugs for various types of animals is a very slow process.
抗体薬は、その高い特異性と低い副作用を持つことから、新しく承認された人間用薬品の大部分を占めています。しかし、さまざまな種類の動物用の薬の開発は非常に遅いプロセスです。
reference:
iGEM Tsinghua-A Team Information iGEM Tsinghua-A Wiki
October 21, 2023
USTC-Software # Prot-DAP,an integrated platform for all steps of protein sequence design # To address the challenges such as cumbersome platform switches and interactive difficulties encountered in the protein sequence design, we have developed Prot-DAP, an integrated protein sequence design assistance platform. It incorporates commonly used protein sequence design tools, allowing users to import sequences of interest from Uniprot, filter homologous proteins for multiple sequence alignment (MSA), score mutations at specific sites using predictive models, and proceed to downstream codon optimization and primer design, providing a comprehensive design pipeline.
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