October 21, 2023
SCIE-PearlDelta # CSF rhinorrhea test kit # A CSF (cerebrospinal fluid) rhinorrhea is the leakage of CSF through the nostrils when there is a fistula between the dura and the skull base. The current diagnostic methods of CSF rhinorrhea are relatively time-consuming, complex, and unspecific, which can cause delayed diagnosis and lead to risk of infected. In our project, we use genetic engineering technique to create a complex of Beta-2-transferrin and mCherry to develop the Beta-2-transferrin detection kit.
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October 21, 2023
Seoul-Korea # Monitro: An innovative nitrate biosensor for the early detection of eutrophication. # Our team realized the seriousness of the excessive eutrophication in South Korea. In this project, our team used two reporter genes (GFP, RFP) along with the PyeaR promoter to allow the usage as an Arduino sensor.
私たちのチームは、韓国での過剰な富栄養化の深刻さを認識しました。このプロジェクトでは、私たちのチームは、Arduinoセンサーとしての使用を可能にするために、PyeaRプロモーターとともに2つのレポーター遺伝子（GFP、RFP）を使用しました。
reference:
iGEM Seoul-Korea Team Information iGEM Seoul-Korea Wiki
October 21, 2023
Shanghai-BioX # Starch shaper: Biosynthesis of high-purity amylopectin for high-performance bioplastics # In order to obtain high-purity amylopectin, the starch synthesis pathway in the plant sweet potato (Ipomoea batatas) was modified using CRISPR/Cas9 system. Firstly, sgRNA oligos targeting the IbGBSSI gene was designed and annealed, and was inserted into the plasmid psgR-Cas9-At to construct the backbone vector, which was combined with the binary vector pCAMBIA1301s to obtain the expression vector.
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October 21, 2023
Shanghai-city # Marvelous Journey of Levan, Unveiling the Magic of Health # Our company, Levan Health, specializes in creating health products using environmentally friendly materials. With a mission to enhance the production of healthcare products, we are dedicated to crafting sustainable solutions for the well-being of our customers. Through careful sourcing and innovative processes, our products not only promote personal health but also contribute to a greener future. Join us in embracing a healthier lifestyle while reducing our ecological footprint.
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October 21, 2023
Shanghai-HS # Development of an optogenetics tool to accelerate CRY2/CIB1 switch off process for diabetes treatment # Diabetes, a prevalent endocrine disorder, is characterized by impaired insulin release and sustained high blood sugar levels. Optogenetic tools, such as the blue-light dependent CRY2/CIB1 switch, have shown promise in disease treatment, enabling noninvasive control of biological processes with precise spatiotemporal resolution. In this study, we combined UVR8, a UVB receptor found in plants, with the recently discovered blue-light inhibitors of cryptochromes BIC2 to create the UVR8N-BIC2 fusion protein.
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October 21, 2023
Shanghai-MedX # Drug screening system for targeting hippo signalling pathway related tumours # According to the World Health Organisation, cancer is one of the leading causes of death globally. In 2020, nearly one in six deaths was caused by cancer, which means that there is a need to develop drugs to treat cancer.
世界保健機関によると、癌は世界的に死亡の主要な原因の一つです。2020年には、ほぼ6人に1人が癌による死亡という結果をもたらし、これは癌を治療するための薬を開発する必要があることを意味します。
reference:
iGEM Shanghai-MedX Team Information iGEM Shanghai-MedX Wiki
October 21, 2023
Shanghai-SDG # Drosophila Sentry: A visible monitoring system for heavy metal pollution # We aim to develop a convenient and inexpensive visual monitoring system for heavy metal pllution by constructing transgenic Drosophila. We inserted MTF-1 gene driven by UAS and Hid gene driven by MRE in Drosophila S2 cells, respectively. These two transgenic Drosophila lines interbreed and the offspring with both MTF-1 and Hid genes cross with the Drosophila line with genotype GMR-GAL4 or Vg-GAL4 or ptc-GAL4 which express GAL4 during eye/wing development.
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October 21, 2023
SHSBNU-China # SynLivPump: Harnessing Synthetic Biology for the Development of Titin Protein Fiber-Enhanced Artificial Heart Valves # Our team ventured to combat the prevalent global challenge of heart valve diseases, affecting millions and demanding innovative, cost-effective solutions. Traditional solutions, biological or mechanical, present significant drawbacks, including limited durability, risk of rejection, and lifelong anticoagulation therapy. Our novel approach employs synthetic biology to leverage the Titin protein’s outstanding mechanical properties, aiming to synthesize superior heart valve materials to enhance bio-compatibility and mechanical resilience.
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October 21, 2023
SHSID-China # E. cool-i: Temperature-based Kill Switch For Engineered Bacteria # Our team, E. cool-i, designed and developed a plasmid kill switch test kit based on temperature to control the growth of engineering bacteria and limit environmental pollution. We conducted surveys and interviewed experts working within the field of bioengineering to understand the impact of our product. Lastly, our team set out to educate the public about microbes through offline lectures, articles, comics, and games.
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October 21, 2023
SMS-Shenzhen # Nucleic Acid Detection Platform Based on CRISPR System # CaPtuRE is an integrated pathogen detection platform that leverages CRISPR/Cas technology, addressing current deficiencies in pathogen testing with a focus on speed and specificity. In response to the COVID-19 outbreak, we have pioneered aerosol sample collection from public events, aiming to integrate CaPtuRE into outbreak forecasting for a comprehensive approach. This platform offers versatility by detecting a range of pathogens and enhancing testing capabilities.
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