October 21, 2023
PIHS-Beijing # Optimization of Human Lactoferrin Expression in E. coli With Addition of Ferric and Ferrous Ions # Lactoferrin is a very important glycoprotein found namely in mammal lactation and colostrum. It plays crucial roles in iron transportation and immunity of neonates. Currently, possible solutions for children without direct access to human lactoferrin are substitution with other mammalian lactoferrin, extracted human lactoferrin from breast milk and recombinant production using eukaryotes.
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October 21, 2023
PINGHE # Cosmetic Bacterial Rapid Test Kit # Our project has developed a novel bacterial detection method that leverages existing gene editing technology. Specifically, we have designed a rapid bacterial test kit for cosmetics. Our motivation for creating this product stems from the issue that individuals often encounter when using cosmetics in their daily lives, particularly with bacteria such as Staphylococcus aureus and Pseudomonas aeruginosa. To address this challenge, we have designed a detection kit for Staphylococcus aureus and Pseudomonas aeruginosa in cosmetics based on CRSPR/ Cas12a gene editing technology, which can be used to rapidly detect the presence of these bacteria.
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October 21, 2023
PLKLFC-1 # Detecting Prostate Cancer - A Painless Transition # Prostate cancer is one of the most common cancers and fifth leading cause of cancer death among men. It is often too late to receive a diagnosis after symptoms appear. For stage 4, the survival rate is only around 50%. While recent diagnostic tests are invasive, risky and expensive, we have created an accurate, safe and non-invasive method that does not require professional involvement.
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October 21, 2023
PLKNPLC-HK # Biodegration and degradation of methylene blue dye by S. elongatus # Dye-containing wastewater discharged from textile industries poses serious threats to aquatic biodiversity and human health. However, traditional physio-chemical methods for treating textile wastewater require high costs and produce secondary waste.
繊維産業から排出される染料を含む廃水は、水生生物の多様性と人間の健康に深刻な脅威をもたらしています。しかし、伝統的な物理化学的方法による繊維廃水処理は高コストがかかり、二次廃棄物を生成します。
reference:
iGEM PLKNPLC-HK Team Information iGEM PLKNPLC-HK Wiki
October 21, 2023
PTSH-Taiwan # Sarcotreat - An engineered live biotherapeutic product that treats sarcopenia # Sarcopenia, a progressive muscle disorder, leads to muscle mass and strength loss with age. After 30, muscle decline is steady, reaching up to 50% by 70, resulting in disability and mortality. Globally, 50 million people suffer from sarcopenia, projected to rise to 500 million by 2050.
サルコペニアは、筋肉の疾患で、年齢とともに筋肉量と力が失われていきます。30歳を過ぎると、筋肉の衰えは着実に進行し、70歳までには最大50％まで達します、これにより障害や死亡率が高まります。世界的には、サルコペニアに苦しむ人々は5000万人に上り、2050年までにはこの数は10倍の5億人にまで増加すると予測されています。
reference:
iGEM PTSH-Taiwan Team Information iGEM PTSH-Taiwan Wiki
October 21, 2023
PuiChing-Macau # Carcinogen detectors: building DNA damage biosensors to support cancer prevention # There are millions of new cases of cancer around the world every year. Current research has been focusing mainly on cancer therapy but not prevention. To reduce cases of cancer and prevent cancer, knowledge about carcinogens is necessary. However, current methods to identify the genotoxic agents are time-consuming testing, involving animal testing and the use of many chemicals.
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October 21, 2023
RainsACA-China # Starfire：Embedded Exploration of Viral Nucleic Acids and Proteins # We design methods for viral RNA research explorations which applied to the HIV-1 isolate ARV-2/SF2 viral genome design for RNA replication for nucleic acid integrase inhibitors, RNA vaccine development, and their potential methods for targeted drug development. Our goal was to utilize the env non-coding long chain RRE RNA and Rev proteins in the viral genome of the HIV-1 isolate ARV-2/SF2 viral strain to develop means that could be used for nucleic acid integrase inhibitors and RNA vaccines as well as targeted drugs.
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October 21, 2023
RBHS-SanDiego-CA # Toxoplasma GONEdii # Toxoplasma gondii is a protozoan parasite that readily infects warm blooded mammals, and is a growing contaminant as a waterborne zoonosis. Additionally, Toxoplasma gondii has an increased prevalence in cats, resulting in transmission to humans and other mammals due to contact with contaminated cat feces. However, there is no current vaccine or drug able to be set as a treatment for T. gondii. In order to address these issues, development of a vaccine to prevent transmission of T.
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October 21, 2023
RDFZ-CHINA # Acnedote: Innovative acne treatment via EGF growth factor and LCFA absorption. # In recent years, acne has emerged as a leading cause of appearance-related anxiety among adolescents, affecting approximately 94-95% of pubertal individuals worldwide. While there are existing topical treatments, their effectiveness is often unsatisfactory. Therefore, we aim to utilize synthetic biology techniques to enhance E. coli Nissle 1917 for acne treatment. For the inflammatory stage of acne, we have engineered the expression of FadL/FadD metabolic pathway proteins to absorb and break down long-chain fatty acids(LCFAs) on the face, reducing inflammation.
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October 21, 2023
Saint-Joseph # Behcheck # Behcheck is a Lateral Flow Assay Test Kit for the presence of HLA-B27 protein. Studies show that this protein variation remains the most important genetic factor for Behçet’s Disease. Furthermore, this specific factor has the highest relation rate among non-phenotypic factors (determined by pathergy tests).
BehcheckはHLA-B27タンパク質の存在を検出する横流し分析試験キットです。研究によれば、このタンパク質のバリエーションはBehçet病における最も重要な遺伝的ファクターのままです。さらに、この特定のファクターは非表現型因子（パシェルギーテストによって決定される）の中で最も高い関連性を持っています。
reference:
iGEM Saint-Joseph Team Information iGEM Saint-Joseph Wiki