October 21, 2023
GEMS-Taiwan # Cure-All Reef: An all-inclusive biofilm-based probiotic delivery system for sustainable coral conservation. # Coral reefs are vital for marine ecosystems and economies, but climate change is causing rapid decline through coral bleaching and disease outbreaks. Probiotics aids corals in fighting environmental stress, but efficient delivery methods aren’t available.
サンゴ礁は海洋生態系や経済にとって不可欠ですが、気候変動によりサンゴの白化や病気の発生による急速な減少が引き起こされています。プロバイオティクスは、サンゴが環境ストレスと戦うのを助けますが、効率的な配送方法はまだ利用できません。
reference:
iGEM GEMS-Taiwan Team Information iGEM GEMS-Taiwan Wiki
October 21, 2023
GreatBay-SCIE # A comprehensive approach aiming at minimizing the harmful influences caused by Achatina fulica # The invasive species Achatina fulica (Giant African Snail) is an infamous culprit triggering a tremendous number of ecological issues worldwide, especially in Shenzhen, China. There are also growing concerns about its primary nematode, Angiostrongylus cantonensis, which results in human lethal diseases. GAStroPurifier is a comprehensive solution aiming at minimizing the harmful influences caused by Achatina fulica, with the six-step solution called ALERTS: ATTRACT snails by α-pinene and isoamyl acetate with fruit odors, LOCK snails with our non-injurious hardware, ELIMINATE the parasites Angiostrongylus cantonensis with synthetic cry protein, REASSURE the killing effects by parasite detection with snail’s mucus before manual TRANSFER, with a kill SWITCH functioned on genetically engineered yeasts for biosafety guarantee.
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October 21, 2023
Guangzhou-MedX # SAFe: Shikimic acid feed for healthy stockbreeding and sustainability # Antibody-free animal breeding protects human health, reduces the problem of resistance, and improves food safety. Shikimic acid (SA) is an important biochemical metabolite in plants and microorganisms that is known for antimicrobial and anti-inflammatory activities. In our project, we engineered the native shikimate pathway of E. coli to accumulate SA more efficiently. We plan to use it as a feed additive for preventive use in livestock breeding during seasons of high disease incidence.
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October 21, 2023
H14Z-AP # Expressing a Tardigrade Protein to Prevent Taupathy in Drosophila # Tauopathy causes Alzheimer’s disease (AD), a common neurodegenerative disease with no cure. New therapeutic strategies are waiting to be discovered. Protein misfolding and cell death are two key features of AD. Scientists have identified a tardigrade protein called CAHS3 that can help protein folding and prevent cell death. In this study, we tested whether CAHS3 expression could attenuate tau toxicity in a fly AD model.
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October 21, 2023
Hangzhou-BioX # Functional Vitamin B2-Enriched Bread to Help Mitigate Malnutrition # Vitamin B2 deficiency can lead to disorders of the mouth, skin, and genitalia. In China, the vitamin B2 deficiency rate is over 85%, but most people are not aware of it. To deal with it, we overexpressed GTP synthetase (ADE4) and vitamin B2 synthetases (RIB1 and RIB7) in the baker’s yeast, Saccharomyces cerevisiae. Bakeries can produce bread and mantou (Chinese steamed bun) by using our yeast at no extra cost, and supply vitamin B2-enriched food for the general public to mitigate malnutrition.
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October 21, 2023
Hangzhou-SDG # Enhanced Biopesticide Based on Metarhizium anisopliae # Chemical pesticides are known to destroy biodiversity and harm human beings. Biopesticides are safer for people and the environment, but lack of efficiency. We improved the efficiency of a fungal biopesticide, Metarhizium anisopliae, by introducing an insect-specific neurotoxin LqhIT2. To improve safety and reduce the risk of gene leakage in the real world, we also introduced a phototoxic suicide switch Pmcl1(short)-SuperNova.
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October 21, 2023
HK-Joint-School # Antimicrobial Black Soldier Fly Ecoplaster # Our project aims to develop a disinfectant hydrogel plaster with a long-lasting sterilizing effect. We address the challenges posed by bacterial infections, which account for a significant global health burden and are the second leading cause of death worldwide.
私たちのプロジェクトは、長時間にわたる滅菌効果を持つ消毒用ハイドロゲル絆創膏の開発を目指しています。私たちは、世界の健康負担の大部分を占め、世界で2番目に死亡原因となる細菌感染による問題に対処します。
reference:
iGEM HK-Joint-School Team Information iGEM HK-Joint-School Wiki
October 21, 2023
HK-SKHLPSS # DNA-Enzyme Duo for Degradation: Using DNA duplex for faster PFAS degradation # Poly-fluoroalkyl substances (PFAs), also named as “forever chemicals”, are large complex groups of synthetic chemicals that are widely used in different consumers products because of its stability to heat, oil, water, etc. Hence, long lead time is needed for PFAs degradation. Research suggested that lignin peroxidase (LiP) and manganese peroxidase (MnP) can work together for PFAs degradation.
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October 21, 2023
HKGTC # QSMiD: Quorum Sensing system for Microplastics Detection # Microplastics are one of the most damaging and lasting legacies emerged from plastic pollution.
マイクロプラスチックは、プラスチック汚染から生じた最も有害で持続的な遺産の一つです。
reference:
iGEM HKGTC Team Information iGEM HKGTC Wiki
October 21, 2023
HKSSC # E. coli biosensor for detection and cleaving of autoinducer among Burkholderia pseudomallei, for reducing virulence # Melioidosis is an infectious disease caused by a gram-negative bacteria Burkholderia pseudomallei containing biofilm in contaminated area, affecting people in Hong Kong with 34 cases including 7 deaths. Since it’s a multi-drug resistant, the conventional therapy for Melioidosis has proven futile and the clinical therapy for Melioidosis last for 20 days. Therefore, to combat this issue, an effective way to prevent the spread of B.
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