October 21, 2023
TSB-Center # The research and development of the monkeypox drug testing kits # Nowadays, many countries and people face the problem of monkeypox. Monkeypox is a zoonotic disease caused by a virus. The pathogen is transmitted from animals to humans. Early symptoms of monkeypox infection include fever, headache, muscle pain, swollen lymph nodes, and tiredness, followed by a blister-like rash. Currently, there is still no effective vaccine or medication to suppress monkeypox.
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October 21, 2023
TSBC-SZ # Gox1 enhances iron death in the treatment of triple negative breast cancer # Breast cancer is a prevalent form of cancer among women, and among its various subtypes, Triple Negative Breast Cancer stands out due to its early onset, high malignancy grade, and poor prognosis. TNBC is characterized by the absence of estrogen/progesterone receptors (ER/PR) and HER2 protein expression, making it challenging to address using conventional therapies. Our project focuses on advancing cancer treatment strategies, particularly for TNBC.
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October 21, 2023
ULC # NATWORK: An “Accelerator” for Nucleic Acid Test # Hi, we are NATWORK from Ulink Shanghai. By using the most recent technology, we developed a phosphorothioated DNA-dependent restriction endonuclease and studied its binding and cutting mechanisms, thereby applying this technique to nucleic acid detection. With the logic understood, we are able to apply point-of-care testing to newly sampled DNA segments, thereby reducing the complex procedure applied to DNA samples, and reducing the time required for testing.
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October 21, 2023
Wego-Taipei # – Not provided yet – # – No abstract provided yet –
– まだ要旨は提供されていません –
reference:
iGEM Wego-Taipei Team Information iGEM Wego-Taipei Wiki
October 21, 2023
WestCentral-HS # RBS mutation-mediated regulation of (S)-estragenol synthesis in E. coli system # (S)-estragenol, a metabolite of soy isoflavones, has high antioxidant capacity. It is effective against cardiovascular disease, wrinkles, hair loss, obesity, and disease. However, only 30%~50% of people can produce (S)-estragenol naturally. Currently, chemical synthesis of (R)/(S)-estragenol mixtures are main procedures used. In our study, (S)-estragenol was heterologously expressed by engineered E. coli, which avoids the use of the expensive inducer ITPG and ensures the purity and production of (S)-estragenol.
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October 21, 2023
WHS-Fremont # – Not provided yet – # – No abstract provided yet –
– まだ抄録が提供されていません –
reference:
iGEM WHS-Fremont Team Information iGEM WHS-Fremont Wiki
October 21, 2023
WIST # Disrupting Quorum Sensing and AHL Signaling to Combat Bacterial Soft Rot Disease in Orchids # Orchids, renowned for their aesthetic appeal, ecological significance, and economic value, face a severe threat from bacterial soft rot disease caused by Dickeya fangzhongdai. This study focuses on combating the pathogen through the disruption of quorum sensing and AHL signaling. Dickeya fangzhongdai employs plant cell wall degrading enzymes (PCWDEs) and quorum sensing to initiate tissue degradation and disease development.
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October 21, 2023
WVHS-SanDiego # Introducing PETase and MHETase into Alteromonas # The abundance of polyethylene terephthalate (PET) plastics in the oceans cause issues for all types of life. The sequential enzymes, PETase and MHETase, found in the soil bacterium Ideonella sakaiensis, have shown degradation of PET plastics through metabolic activity. However, because I. sakaiensis is found mainly in soil, it is not an ideal host when attempting to degrade PET plastics in the ocean.
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October 21, 2023
XHD-WuHan-China # Biosensor technology applied to innovative solutions for p-cresol monitoring # In industrial production, the monitoring of cresol contamination has always been an important issue. Traditional chemical and physical methods, while accurate, have cost and operational limitations, so many plants choose not to monitor cresol. To address this challenge, new biosensor technologies have emerged. We took advantage of the high sensitivity and specificity of biomolecules to modify E. coli, and combined with the design of the color development module and the cutting module, we can quickly monitor the cresol concentration on site and continuously monitor the cresol concentration in real time.
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October 21, 2023
XHD-WuHan-Pro-China # A microplastic treatment device for performing functions of Escherichia coli # The sea, which is supposed to be clean and clear, is now covered by plastic garbage, and microplastics will endanger human safety with enrichment. In previous studies, we found that surface display technology can display PETase on the surface of engineering bacteria and degrade microplastics in the environment. In order to ensure that the engineering bacteria will not spread in the water, we referred to the content of the Lithuanian igem team in 2022 to express the cellulose-binding protein in the engineering bacteria, and then added the cellulose component to the microplastic treatment device to anchor the engineering bacteria in the microplastic treatment device to prevent biological pollution.
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