October 21, 2023
NYU-New-York # At-home Iron Level Detection Using Salivary Ferritin # The problem of iron deficiency anemia affects close to 25% of the global population and most heavily those of lower socioeconomic status (StatPearls). Currently, iron levels are most commonly detected by labs testing blood samples from patients which can be expensive and time consuming. We’re creating a non-invasive method to measure iron levels by detecting salivary ferritin, a protein that stores iron, using a peptide or DNA aptamer.
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October 21, 2023
Oxford # De Novo Protein Biosensor for Water Contamination in Limited-Resource Setting # The lack of accessible, safe fresh water is becoming more than ever a humanitarian crisis, with its consequences particularly devastating regions with limited resources. To combat this problem, international stakeholders (UNICEF, WHO, etc.) recognise the urgent need for a field water testing tool that 1) offers people rapid, easy readout of water contamination levels to avoid potential health hazards and 2) collects reliable, consistent data for analysing the scale of regional contamination.
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October 21, 2023
Patras # Hyperion # Project Hyperion is a pioneering venture focused on developing a cutting-edge biosensor with a primary objective: early cancer detection and the identification of various anomalies through the analysis of kinome hyperphosphorylation patterns. Our journey commences with the precise construction of the biosensor and its components, primarily executed through advanced 3D printing techniques. Concurrently, we initiate the cultivation of human cell lines, specifically employing the A453 cell lines sourced from the European Collections of Authenticated Cell Cultures, forming the foundation for rigorous testing and critical assessment of the biosensor’s functionality.
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October 21, 2023
PennState # SensoREX: Riboswitch-Enabled eXpression # Waiting for diagnostic test results can be an anxious and lengthy process, often taking several days or even weeks; however, the Penn State iGEM team has implemented a more efficient method of analysis with SensoREX! SensoREX utilizes Riboswitched-Enabled eXpression in cell-free systems to measure biomarker concentrations. This quicker, cheaper, and modular in vitro diagnostic could easily be designed to identify a variety of disease-indicating proteins and small molecules.
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October 21, 2023
SMBU # The Genome Detective: Universal biosensor for CRISPR-Cas activity evaluation. # CRISPR-Cas technologies hold immense potential for next-generation gene therapy. However, because of the complex genome structure and potential irreparable consequences, these technologies must be thoroughly tested. To address this, we propose a universal cellular biosensor capable of rapidly and accurately assessing the activity of genome editing systems without the need for complex sequencing.
CRISPR-Cas技術は、次世代遺伝子治療に非常に大きな可能性を持っています。しかし、複雑なゲノム構造と修復不可能な結果の可能性のため、これらの技術は徹底的にテストされる必要があります。これについて対応するために、複雑なシークエンスングが不要で、迅速かつ正確にゲノム編集システムの活性を評価できる普遍的な細胞バイオセンサーを提案します。
reference:
iGEM SMBU Team Information iGEM SMBU Wiki
October 21, 2023
TokyoTech # STAND UP # Our goal is to contribute to the achievement of SDGs, specifically Goal 3 and 10. To tackle the rising incidence of dengue fever, which affects 96 million people annually, we at iGEM TokyoTech have developed a low-cost, high-sensitivity, high-throughput testing method. Our system uses glowing cells coupled with an enhanced PCR assay to identify both past and current infections. We aim to share this data with the public and governments, promoting good health for all and working towards eliminating health inequalities.
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October 21, 2023
Tongji-China # Plink：A High-precision Quantitative Detection System Based on High Conductivity Pilus # This year, Tongji-China aims to pioneer a fast, simple, economical, sensitive, and portable real-time quantitative antibody detection system. Our project is inspired by a unique biomaterial: Electrically conductive pili (e-pili) derived from G. metallireducdens. This pili is currently the most conductive biomaterial discovered by humans, and its conductivity is highly sensitive to changes in surface charge distribution.
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October 21, 2023
TU-Braunschweig # Riboswitch-based Quantification of Lithium in Samples using a Point-of-Care Test System # Our project, Li+On-Switch, aims to develop a test system for monitoring lithium levels in patients’ samples, which can be easily, safely, and reliably used at home. Lithium preparations are commonly administered to patients with bipolar and act as mood stabilizers. Due to the risk of lithium intoxication, regular monitoring of lithium levels in the blood is necessary.
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October 21, 2023
UGM-Indonesia # Novel Biodevice for Colorectal Cancer Screening using Escherichia coli Nissle 1917 with miRNAs as Biomarker # Colorectal Cancer (CRC) screening is still difficult to access in rural areas even though early screening significantly reduces cancer mortality. We developed a novel screening method by utilizing Loop-Initiated RNA Activator (LIRA) OR Gate system to detect miR-21 and/or miR-92a as early biomarkers of CRC assembled within endogenous pMUT1 plasmid that were engineered into Escherichia coli Nissle 1917 (EcN) probiotic chassis.
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October 21, 2023
UiOslo-Norway # Detection of endometriosis associated miRNA with Cas proteins # Endometriosis is a disease that affects women of reproductive age worldwide, caused by the abnormal growth of the endometrial lining outside of the uterus. While the disease can cause various symptoms, the most common are varying degrees of pain and discomfort. This has individual effects and socioeconomic implications, such as increased sick leave and mental health issues.
子宮内膜症は、全世界の生殖年齢の女性に影響を与える病気で、子宮の外側で子宮内膜の異常な成長によって引き起こされます。この病気はさまざまな症状を引き起こすことがありますが、最も一般的なものは痛みと不快感の度合いです。これには個々の効果と社会経済的な影響があり、病気休暇の増加や精神的健康問題などがあります。
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