IISER-TVM # OASYS - A Novel FRET based microfluidic device to aid MDD diagnosis # Major depressive disorder(MDD) is a complex clinical syndrome and is predicted to be the leading cause of disease burden worldwide by 2030. うつ病（MDD）は複雑な臨床症候群であり、2030年には世界的な疾病負担の主な原因と予測されています。 reference: iGEM IISER-TVM Team Information iGEM IISER-TVM Wiki
IIT-Roorkee # NeuraSense # Our project focuses on the development of a groundbreaking diagnostic method for early Alzheimer’s disease detection, utilizing DNA aptamers in saliva samples. This innovative approach offers a non-invasive and cost-effective means of identifying Alzheimer’s biomarkers, addressing the critical need for early diagnosis in a rapidly aging global population. By harnessing the unique binding properties of DNA aptamers, we aim to create a highly specific and sensitive diagnostic tool that can detect Alzheimer’s-related proteins or genetic markers in saliva. ...
KCL-UK # Revolutionizing Colorectal Cancer Detection: Harnessing Gas Vesicles and Ultrasound for Early Diagnosis # According to WHO, colorectal cancer is the second most deadly and the third most common cancer worldwide. Early diagnosis significantly reduces mortality rates. As a result, the KCL_UK iGEM team embarked on a project aimed at revolutionising diagnostics. Our approach involves genetically modifying an E.coli to sense lactate produced by cancer cells and make gas vesicles, which can be detected by ultrasound imaging. ...
KUAS-SEOUL # Capture Cervical Cancer with CEApture # Our team aimed to develop a user-friendly cervical cancer testing kit, with a particular focus on facilitating early diagnosis. Sanitary pad integrated with a biosensor for routine cervical cancer screening was designed. We diagnose cervical cancer using biomarker, CEA, that can be identified by aptamer N56. CEApture shows how our biosensor works, in which the Aptamer captures the CEA protein. Through experiments and computational analysis, clinical viability of the CEA protein and N56 aptamer binding characteristics for application in an LFA sensor was evaluated. ...
McMaster-Canada # BACTRACK: AN INGESTIBLE BIOSENSOR FOR THE CHARACTERIZATION OF GUT METABOLITES RELATED TO MAJOR DEPRESSIVE DISORDER # Ambiguity in the DSM criteria of major depression disorder (MDD) exacerbates the challenges that clinicians and scientists face in its clinical assessment and research. Investigations of biomarkers related to MDD have highlighted the importance of the gut-brain axis in influencing mental health. An increase in Indole and a decrease in butyrate, tetrahydrofolate, and hydrogen peroxide concentrations has been noted in individuals with MDD, while tetrathionate is highly positively correlated with gut inflammation. ...
Michigan # SNP-IT: A Single Nucleotide Polymorphism Detection Platform to Inform Antiplatelet Pharmacotherapy # Antiplatelet medications are a common treatment for patients after experiencing thrombotic events, such as venous thromboembolism or some forms of stroke. Recently, a genetic variant— the rs773902 single nucleotide polymorphism (SNP)—was identified that may reduce efficacy of a standard-of-care antiplatelet regimen, aspirin and clopidogrel. This SNP is present in a diverse range of individuals, but is especially prevalent in those of African descent. ...
Missouri-Miners # myRNA: A Novel Approach to Early-Stage Breast Cancer Detection # Breast cancer is a disease in which cells in the breast grow uncontrollably, and it is the second most common cancer among women in Missouri and in the United States. One way to detect instances of breast cancer is to screen for microRNAs associated with breast cancer cell lines, which are present in the urine. We created a device similar to a pregnancy test designed to detect early-onset breast cancer using methods that are easier and less invasive than traditional methods. ...
Montpellier # Aedes’n seek, searching pathogens in mosquitos. # Abstract : Our primary objective was to create a robust pathogen detection system and transmit the information directly to researchers. After numerous iterations, with an initial focus on the West Nile virus sequence, Cas13a protein, and guide RNA, we proudly introduce the prototype of this cutting-edge system. This versatile model forms the basis for detecting a range of pathogens, including diseases like dengue and chikungunya. ...
NTHU-Taiwan # NanoCircDx # Research has demonstrated that early detection can make colorectal cancer highly curable. Therefore, we have decided to develop a diagnostic technology platform for cancer screening using liquid biopsy. With just a blood sample provided by the patient, we can determine the potential presence of colorectal cancer through circular RNA analysis in the serum. NanoCircDx presents clear benefits compared to existing methods for colorectal cancer detection. ...
NYCU-Taipei # The Legend of VigilaGuard # According to the data from the World Health Organization, diseases related to inflammation contribute to more than 50% of global deaths. Our team aims to develop a non-invasive, accessible, and affordable bifunctional biodevice that can perform real-time detection of inflammatory responses. We designed an engineered bacteria that can detect target inflammatory biomarkers. The detection results will be transferred into signals like fluorescent protein expression or electric currents in the bacteria. ...