October 21, 2023
AFMU-China # DNA-RNA chimeric circular probe-based DSN/Cas12a double enzymatic plasma trace microRNA detection system # The metabolic syndrome (MetS) is a common metabolic disorder caused by many risk factors, such as hypertension, dyslipidemia and central obesity, which increases the risk for cardiovascular disease, type 2 diabetes and even colon cancer. Nowadays, MetS has become one of the major public-health challenges worldwide. However, lack of early diagnosis hinders the timely awareness of MetS.
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October 21, 2023
Athens # ScentiPD # The goal of our project is the creation of a portable diagnostic kit for the detection and quantification of specific Volatile Organic Compounds (VOCs) from skin sebum. Those compounds have been associated with Parkinson’s Disease (PD), with evidence pointing to their change in concentration occurring long before the evident onset of the disease. The alternative way to measure these compounds would be a GC/MS machine, with obvious drawbacks.
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October 21, 2023
BPI-China # Detection of mutiple miRNAs based on isothermal amplification on colloidal gold and CRISPR technology # Myocardial infarction is a common disease worldwide. There are approximately 330 million current heart attack victims in China. miRNA was considered as one of the most potential new biomarkers of myocardial infarction.Therefore, the development of miRNA detection methods is of great significance. The design idea of this project was to modify the hairpin structure on the surface of colloidal gold particles, and then the target miRNA could open the hairpin structure to initiate isothermal amplification reaction.
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October 21, 2023
BUCT-China # POMELO:Polymerase- enabled Molecular Computing # Biological molecule diagnostics hold great promise in the field of healthcare. The BUCT-China team has developed DNA molecular probes capable of weighted summation calculations through polymerase-mediated strand displacement reactions. These probes, organized into an artificial biochemical circuit resembling a neural network structure, can execute weighted summation on multidimensional biomarker input signals, providing more intuitive low-dimensional diagnostic results for in vitro diagnostics and disease identification.
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October 21, 2023
CCU-Taiwan # CTC-FAST: How we fight against lung cancer # あなたはiGEMコンペティションの審査員です。iGEMチームからのプロジェクト紹介が提出されました。追加の文や説明を付け加えることなく、以下の英文を正確でわかりやすい日本語に翻訳してください。
reference:
iGEM CCU-Taiwan Team Information iGEM CCU-Taiwan Wiki
October 21, 2023
CJUH-JLU-China # BreFast: A Fast and Convenient Screening Kit for Breast Cancer Early Detection # While breast cancer is the cancer with the highest incidence rate among women, early detection reduces the mortality rate of breast cancer effectively. Therefore, we aim to create a fast and convenient screening kit, BreFast, for breast cancer early detection. We employed comprehensive bioinformatics methods to identify a breast cancer-associated miRNA, miR-21-5p, as an optimal biomarker for screening, and engineered a CRISPR/Cas13a system that could be specifically activated by miR-21-5p to cleave any by-stander RNA such as a dual-labeled reporter RNA.
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October 21, 2023
Concordia-Montreal # SYNCOVA: screening method for early & sensitive detection of ovarian cancer with therapeutic implications # Ovarian cancer accounts for the most deaths amongst all gynecological cancers. A staggering 80% of patients are diagnosed in the late stages of this illness, which is mostly due to its seemingly benign symptoms and the lack of a standard screening test. Those who are diagnosed in the late stages of ovarian cancer have between 15% to 25% chance of surviving past five years.
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October 21, 2023
DUT-China # Modec-Modular detection tool based on Mi3 protein cage # Protein cages, self-assembled structures from multiple copies of subunits, offer distinct advantages. Their functionalization has garnered substantial interest in synthetic biology. Despite extensive engineering efforts in various fields, their potential as a diagnostic platform has not been fully explored. Here, we present a versatile “plug and play” diagnostic platform built on engineered protein cages. Our study reveals that the fusion of SpyCatcher preserves the integrity and structure of Streptavidin.
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October 21, 2023
FAU-Erlangen # GLOW.coli - with Bacteria against IBDs # The importance of gut health has gained significant recognition in recent years. Research has shown that the composition of the gut microbiome, can help in the prevention or exasperation of Inflammatory Bowel Diseases (IBDs). New studies have specifically linked IBD development to gut dysbiosis, a changed gut microbiome composition associated with a reduction in beneficial bacteria and associated compounds.
近年、腸の健康の重要性が大きく認識されるようになりました。研究によると、腸内微生物叢の構成は、炎症性腸疾患（IBDs）の予防や悪化の助けになることが明らかになっています。新たな研究では、IBDの発症は腸内細菌叢の異常（腸内の細菌叢の構成が変わり、有益な細菌とそれに関連する化合物が減少する状態）と具体的にリンクしていることが示されています。
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October 21, 2023
Groningen # Bye-o-film: Combating Medical Implant-Related Biofilm Infections # Bye-o-film tackles implant-related infections in prosthetic joint surgeries, driven by rising cases due to factors like obesity and an aging population. We propose an E. coli-based biosensor for early biofilm detection on implants and explore modified bacteriophages to disrupt biofilms, reducing antibiotic dependence. We designed a fluorescent protein-based biosensor reporter, and an electronic device sensor, accompanied by complementary software. Our mission includes raising awareness, advancing biosensors, and promoting phage therapy.
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