October 21, 2023
Warwick # Engineering a Self-Regulating Feedback Loop in E. coli for Perillyl Alcohol Production # Limonene and perillyl alcohol (PA) are naturally occurring chemical compounds with applications in the food, cosmetic, and cleaning industries. More notably, perillyl alcohol in particular, has shown very promising results in clinical testing as an anticancer drug treating carcinomas, and tumours and acting as a chemoprotectant for skin. With the demand already increasing year by year, these potential implementations will only increase the need for limonene/PA.
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October 21, 2023
Westlake-China # Biosynthesis and Applications of Iron Oxide Nanoparticles # We’re trying to develop a new treatment for breast cancer based on the iron oxide nanoparticles linked with antibody targeting HER2 protein on some breast cancer cells. We are using a green biological method to synthesize the IONPs by the E. coli dircetly with ferric ions as the inducer. We choose to synthesize the IONPs and the antibody separately as self-assembly is still hard when the coating composition of IONPs is now clear.
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October 21, 2023
XJU-China # Genetic Shield # Microorganisms have a wide range of applications in pharmaceutical, chemical, agricultural and experimental fields. Various metabolic engineering modification strategies and techniques have been used to build E.coli and yeast cell factories. However, microorganisms can fail to survive properly or even die due to veorly alkaline or saline environments during culture and production.
微生物は、製薬、化学、農業、実験の各分野に幅広く活用されています。さまざまな代謝工学改変戦略と技術が使われて、E.coli（大腸菌）や酵母の細胞工場を構築しています。しかし、微生物は培養や生産の過程で、非常にアルカリ性や塩分環境により適切に生き残ることができず、あるいは死んでしまうことがあります。
reference:
iGEM XJU-China Team Information iGEM XJU-China Wiki
October 21, 2023
Yale # De Novo Biosynthesis of Daidzein for the Production of (S)-Equol # Menopause affects the majority of women approaching the age of 50 and introduces a host of adverse symptoms, such as cardiovascular diseases, and vasomotor and musculoskeletal issues. (S)-equol, an isoflavandiol estrogen produced in the human gut microbiome, has been found to help alleviate post-menopausal symptoms with minimal health risks. However, its effectiveness in the human gut is limited by its low production levels.
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