October 21, 2023
OUC-China # Turn waste cooking oil into MCAFs and their derivatives # 2023 OUC-China igem team focuses on the green production of medium chain fatty acids and their derivatives.Firstly, MEL (Mannose-erythroitol) is produced by Moesziomyces aphidis XM01 using waste cooking oil as substrate, and a large number of medium chain fatty acids are obtained by hydrolyzing MEL. Due to the coexistence of different fatty acid pathways in XM01 strain, a large amount of MEL is formed and the accumulation of intracellular oil is caused.
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October 21, 2023
Purdue # – Not provided yet – # – No abstract provided yet –
– まだ概要が提供されていません –
reference:
iGEM Purdue Team Information iGEM Purdue Wiki
October 21, 2023
Rochester # The 3D bioprinting solution: harnessing microbes for sustainable compound synthesis # RoSynth engineered a 3D bioprinter for optimizing the production of in-demand plant-derived molecules. Along with medicinal uses, plant-derived molecules have formed the basis of dyes, cosmetics, rubber, waxes, and flavorings for thousands of years. As climate change is impacting the availability of plants, there is an increasing need for local, stable and efficient plant biomolecule synthesis. Our team built the first home-built two-channel 3D bioprinter that is capable of printing our engineered prokaryotic and eukaryotic hydrogel parallel culture system in a cost effective manner.
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October 21, 2023
SCUT-China # ECO-SHELLS：Waste to Wealth # When people buy seafood or make seafood products, they aim to get nutrition from those eatable and savory parts, hardly paying attention to the waste like shell of shrimps and crabs. SCUT-China wants to upgrade the usage of these biomass waste. lnstead of landfill and banishing shell waste in the ocean, we aim to develop a new strand of streptomyces to valorize the waste, producing chemicals that is beneficial to human, making good use of the fermentation broth.
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October 21, 2023
SDU-CHINA # Cell Intelligence (CI) for PHB Production # Traditional petroleum-based plastics are accumulated in environment at a very high rate and are harmful to our human being. In order to cope with this crisis, we have decided to increase the production of degradable plastics, and PHB has entered our vision due to its high biocompatibility, high degradation ability, and non-toxicity. However, due to the high production cost, PHB cannot be widely used.
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October 21, 2023
UChicago # GLOW: Green Levothyroxine Optimized with Transaminases # The project transaminase-mediated synthesis of levothyroxine aims to innovate levothyroxine production, a critical drug for hypothyroidism treatment. Traditional methods involve low yields and environmental challenges, notably the need for racemate resolution. By integrating transaminase enzymes known for high substrate specificity and stereoselectivity, we intend to simplify the synthesis process, improve yield, and reduce byproducts. Our team’s multi-disciplinary approach focuses on optimizing the L-tyrosine-based synthesis pathway for levothyroxine, with the ultimate goal of setting new standards in sustainable pharmaceutical production.
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October 21, 2023
UFlorida # Multifaceted Model to Study Sepsis Progression # Sepsis is defined as the body’s extreme response to infection and causes immune dysregulation, which leads to inflammation and a cascade of changes that damages organ systems. The pathophysiology of sepsis is inextricably linked to bone marrow, as the hematopoietic niche controls the proliferation of myeloid and lymphoid progenitor cells in peripheral blood and boosts local immune response. Tracking the progression of sepsis and predicting the clinical outcome is difficult, as no model exists that accurately mimics human physiology or immune trends.
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October 21, 2023
USP-EEL-Brazil # CBDynamics # Cannabidiol (CBD) is a valuable medical compound known for its numerous therapeutic benefits, particularly in treating epilepsy patients. However, in Brazil, its acquisition is shrouded in bureaucratic and legal complexities, primarily stemming from its association with Cannabis sativa. Therefore, this study aims to produce cannabidiolic acid (CBDA), the direct precursor to CBD, using biosynthesis and recombinant gene technology with Saccharomyces cerevisiae yeast. This production involves two essential pathways: the geranyl diphosphate (GPP) one, already present in the yeast metabolism, and the olivetolic acid rote.
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October 21, 2023
USTC # TAGO–Diet Sugar Tagatose Production with Thermotolerant Yeast # Overconsumption of sugars are partly related to the growing rates of obesity and diabetes. Tagatose, a rare hexose, is almost as sweet as surcose while its caloric content is lower. In our project, we engineerd two different metabolic pathways, one using isomerase and the other using reductase and dehydrogenase, to product tagatose with lactose in Kluyveromyces marxianus, a thermotolerant yeast.
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October 21, 2023
Vilnius-Lithuania # Exullose – unlocking the potential of biomaterials # Researchers have shown an ever-growing interest in bio-based materials, driven by their sustainability and versatility for various industrial applications. Our quest for the ideal material to meet the demands of a complex world was accomplished by employing genetic engineering principles. We have created synthetic biology tools for in vivo alterations of bacterial cellulose composition in Komagataeibacter xylinus. This system was utilized to modify the cellulose polymer in three different ways: (1) bacterial cellulose-chitosan polymer was produced after cellulose-chitin deacetylation.
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