October 21, 2023
LINKS-China # Aroma Anchor # AmbergrisĀandĀSandalwoodĀOilĀareĀbothĀwell-knownĀfragranceĀfixativesĀsinceĀcenturiesĀbefore. However, people hunted and killed sperm whales to obtain ambergris and the growing of sandalwood is highly time and cost consuming. LINKS-China 2023 aims to produce ambrein and santalol, the major components of the fixatives using yeast cell-factory. By engineering S.cerevisiae, we optimized the MVA pathways by over expressing tHMG1 and IDI1. Then, we constructed the pathway of santalene production by expressing ClSS and its mutant.
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October 21, 2023
SCU-BSE-China # YEAST PATRONUS: Polyamines Assist TheRmO and NatUral Support # Biomanufacturing, characterized by its green and efficient features, is poised to be the future production method to replace traditional chemical manufacturing. Yeast cell factory has been widely applied in practical production. However, multiple stress challenges(such as high temperature and extreme pH environments) during the fermentation process significantly reduce its availability. Enhancing its tolerance can substantially reduce production costs and energy consumption, expanding the application scope of yeast cell factories.
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