October 21, 2023
BNUZH-China # FeFighterS – Engineered Bacteria Induce Ferroptosis in Tumor Cells # In this project, we have developed a novel strategy that utilizes attenuated Salmonella typhimurium VNP20009 to induce ferroptosis in tumor cells. To further enhance the tumor targeting ability, we had genetically modified VNP20009 to express single chain antibody fragments on the outer membrane. Once the engineered bacteria reached the tumor tissue, it will secrete glucose oxidase into the tumor cells, mediating the occurrence of the Fenton reaction.
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October 21, 2023
Jilin-China # Mela-no-more —-Innovative Bacterial Therapy for Targeted Treatment # Melanoma, characterized by its aggressive nature, high incidence, and tendency for metastasis, results in significant cases and deaths on a global basis. The current therapeutic methods suffer from problems such as poor efficacy and strong side effects year, highlighting an urgent need to alternative treatment. This year Jilin-China aims to achieve regulated and precise treatment of melanoma. E.coli Nissle1917, a kind of non-pathogenic bacteria is selected and equipped with three systems: the regulatory system controlling the expression of engineered bacteria, and therapeutic genes carefully screened to achieve effective treatment, with Toxin-Antitoxin system ensuring bio-safety.
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