Ohio-State-FABE

October 21, 2023

Ohio-State-FABE # DiGI-T3 - Digitally Optimized Gastrointestinal Therapeutics for Type 3 Secretion # Many diseases result from dysfunctional proteins, but therapeutics directly targeting them are limited. Current treatments, mainly small molecules, cause side effects. Ohio State’s iGEM team is exploring a solution using Type III Secretion Systems (T3SS) for continuous therapeutic protein delivery. Although native to some infectious bacteria, T3SS can be modified for safe use in Escherichia coli to deliver therapeutic proteins, particularly targeting gastrointestinal diseases. ...