(s)-estragenol-synthesis

WestCentral-HS

October 21, 2023
(s)-estragenol-synthesis, rbs-mutation-mediated-regulation, e.-coli-engineering
high-school

WestCentral-HS # RBS mutation-mediated regulation of (S)-estragenol synthesis in E. coli system # (S)-estragenol, a metabolite of soy isoflavones, has high antioxidant capacity. It is effective against cardiovascular disease, wrinkles, hair loss, obesity, and disease. However, only 30%~50% of people can produce (S)-estragenol naturally. Currently, chemical synthesis of (R)/(S)-estragenol mixtures are main procedures used. In our study, (S)-estragenol was heterologously expressed by engineered E. coli, which avoids the use of the expensive inducer ITPG and ensures the purity and production of (S)-estragenol. ...