riboswitch

Freiburg

October 21, 2023
cellect, riboswitch, toxin-antitoxin-mechanism
foundational advance

Freiburg # CELLECT - Self-Regulating System to Ensure Phenotypic Stability in Microbial Cultures # Phenotypic instability in microbial cultures severely limits the applicability of synthetic biology. Be it for plastic degradation or vitamin synthesis, persistent gene expression is a must. Therefore, we have created CELLECT, an innovative autoregulatory system that makes microbial survival dependent on the existence of a target molecule. The system integrates a riboswitch, specific to the target compound, linked to a toxin-antitoxin mechanism that regulates cell survival. ...