protein-based-therapeutics

UBC-Vancouver

October 21, 2023
protein-based-therapeutics, cell-free-protein-synthesis-(cfps), intein-mediated-biosynthesis
foundational advance

UBC-Vancouver # PILOT: Platformed Inteins: A linked orthogonal toolkit # Protein-based therapeutics have been approved for clinical use due to their unique structural and functional properties. However, high throughput production of novel therapeutic proteins is hindered by cellular cytotoxicity and resource intensity of conventional manufacturing methods, entailing slow turnaround times. Synthetic biology technologies have emerged to eliminate such barriers to whole-cell protein production in vitro by harnessing cell-free protein synthesis (CFPS). ...