SUSTech-CHINA

October 21, 2023

SUSTech-CHINA # Construction of protective probiotics for precise prevention and control of drug-resistant biofilm # Bacterial biofilm is an environmental adaptation structure formed by microorganisms. After reaching maturity biofilms, intestinal pathogens will develop resistance to antibiotics and host immunity, elicit infection repeatedly, and induce diarrhea or inflammation of the gastrointestinal tract. In mature biofilms, the network structure formed by eDNA is crucial for the maintenance of biofilm stability. The objective of this endeavor was to modify Nissle 1917 so that it could identify Pseudomonas aeruginosa, stimulate the production of recombinant HMGB1 protein and PslG polysaccharide enzyme, degrade the compact structure established by eDNA, and eradicate resistance to biofilm. ...