SYSU-Software

October 21, 2023

SYSU-Software # BioRocket: Systematic Discovery of Novel Protein Delivery Systems in Massive Prokaryotic Genomes # Prokaryotes have evolved various protein delivery systems that enable these organisms to interface with host cells. One example, the extracellular Contractile Injection Systems (eCISs) are syringe-like protein complexes that can inject proteins into host cells. Despite the potential as programmable protein delivery tools, only a few eCISs have been characterized. Here, we designed the BioRocket platform to systematically mine eCISs from prokaryotic genomes using machine learning and structure-based protein alignment methods. ...