probiotic-expressed-gastric-intrinsic-factor

Guelph

October 21, 2023
bloombiota, vitamin-b12-deficiency, probiotic-expressed-gastric-intrinsic-factor
food & nutrition

Guelph # Project BloomBiota: Combatting vitamin B12 Deficiency with probiotic-expressed gastric intrinsic factor # Project BloomBiota aimed to create a probiotic containing enriched B12 and human gastric intrinsic factor (hGIF) to combat vitamin B12 deficiency, which disproportionately affects women, vegetarians, and the elderly. Through one pill containing the probiotic strain of Escherichia coli Nissle 1917, an individual receives a B12 supplement and increased absorption. BloomBiota is novel because it aims to express hGIF in the bacterial periplasm instead of the cytoplasm, which increases the chances for proper folding, resulting in a functional protein. ...