October 21, 2023
Gifu # Crispr ageinst resistance # Our Gifu team is focused on addressing future antibiotic-resistant bacterial infections using the Cas system. We aim to eliminate the genes contributing to this resistance, thus neutralizing the bacteria’s defense and halting their spread. The CRISPR-MultiTargeter tool aids in designing gRNAs targeting common parts of these bacteria, ensuring effectiveness despite mutations. We aspire to integrate this system into phages for efficient phage therapy, offering a novel approach to counteracting the escalating issue of drug-resistant bacteria.
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October 21, 2023
Groningen # Bye-o-film: Combating Medical Implant-Related Biofilm Infections # Bye-o-film tackles implant-related infections in prosthetic joint surgeries, driven by rising cases due to factors like obesity and an aging population. We propose an E. coli-based biosensor for early biofilm detection on implants and explore modified bacteriophages to disrupt biofilms, reducing antibiotic dependence. We designed a fluorescent protein-based biosensor reporter, and an electronic device sensor, accompanied by complementary software. Our mission includes raising awareness, advancing biosensors, and promoting phage therapy.
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