loop-initiated-rna-activator

UGM-Indonesia

October 21, 2023
colorectal-cancer-screening, escherichia-coli-nissle-1917, loop-initiated-rna-activator
diagnostics

UGM-Indonesia # Novel Biodevice for Colorectal Cancer Screening using Escherichia coli Nissle 1917 with miRNAs as Biomarker # Colorectal Cancer (CRC) screening is still difficult to access in rural areas even though early screening significantly reduces cancer mortality. We developed a novel screening method by utilizing Loop-Initiated RNA Activator (LIRA) OR Gate system to detect miR-21 and/or miR-92a as early biomarkers of CRC assembled within endogenous pMUT1 plasmid that were engineered into Escherichia coli Nissle 1917 (EcN) probiotic chassis. ...