immunotherapeutic-strategy

IISc-Bengaluru

October 21, 2023
endometriosis, mrna-based-therapeutics, immunotherapeutic-strategy
therapeutics

IISc-Bengaluru # MetraMorpheus, our attempt to treat Endometriosis non-invasively, using the power of mRNA! # We propose a unique, immunotherapeutic strategy to combat endometriosis. Largely, we aim to produce the antibody O-1L8-15 to block Interleukin-8 (CXCL8), a chemokine advancing endometriosis. A previous study used monoclonal antibodies to block IL8, reducing endometriotic tissue volume in monkey models. Our goal is to specifically target the peritoneal concentration of IL-8, using biochemistry and microfluidics to attach an aptide to an LNP, enhancing disease specificity. ...