Jiangnan-China

October 21, 2023

Jiangnan-China # Efficient stereoselective hydroxylation of deoxycholic acid by the robust whole-cell Cytochrome P450 CYP107D1 biocatalyst # Deoxycholic acid (DCA) has been authorized by Federal Drug Agency for the cosmetic reduction of redundant submental fat. The hydroxylated product (6β-OH DCA) was developed to improve the solubility and pharmaceutic properties of DCA for further applications. Herein, a combinatorial strategy was applied to construct a powerful Cytochrome P450 biocatalyst (CYP107D1, Olep) to convert DCA to 6β-OH DCA. ...