gene-circuit

Duke

October 21, 2023

chimeric-antigen-receptor, solid-tumors, gene-circuit

therapeutics

Duke # ICARUS - Intelligent Chimeric Antigen Upregulation System # Chimeric antigen receptor (CAR) T-cell therapy has shown great promise in treating certain hematologic cancers by reprogramming patient T-cells to target tumor antigens. However, application of this therapy to solid tumors has been limited by issues such as heterogeneity of antigen expression, tumor inaccessibility, and immunosuppressive tumor microenvironments. Our project describes an integrated CAR-synNotch circuit, the Intelligent Chimeric Antigen Receptor Upregulation System (ICARUS), to address these limitations. ...

Manual-KY

October 21, 2023

pfas-detection, gene-circuit, molecular-dynamics-modeling

high-school

Manual-KY # PFAS Detection and Characterization -inator # PFAS (per and poly fluoroalkyl substances) are an increasingly prevalent threat. PFAS are industrial products that are resilient to degradation and widespread in the environment, including our home state of Kentucky. PFAS are responsible for a variety of human diseases, such as cancers, birth defects, autoimmune responses, and many more characterized and potentially uncharacterized impacts. PFAS testing is also very inaccessible, requiring mass spectroscopy machines that not many places have. ...