ferroptosis-in-tumor-cells

BNUZH-China

October 21, 2023
engineered-bacteria, ferroptosis-in-tumor-cells, toxin-antitoxin-system
therapeutics

BNUZH-China # FeFighterS – Engineered Bacteria Induce Ferroptosis in Tumor Cells # In this project, we have developed a novel strategy that utilizes attenuated Salmonella typhimurium VNP20009 to induce ferroptosis in tumor cells. To further enhance the tumor targeting ability, we had genetically modified VNP20009 to express single chain antibody fragments on the outer membrane. Once the engineered bacteria reached the tumor tissue, it will secrete glucose oxidase into the tumor cells, mediating the occurrence of the Fenton reaction. ...