escherichia-coli-nissle-1917

NWU-CHINA-A

October 21, 2023

inflammatory-bowel-diseases, engineered-probiotics, escherichia-coli-nissle-1917

therapeutics

NWU-CHINA-A # Super Probiotics: Intestinal Knight Engineered Bacteria Beat IBD # Our project focuses on the treatment of Inflammatory Bowel Diseases ( IBD ) by constructing engineered probiotics . The concentration of reactive oxygen species ( ROS ) is an important factor in the occurrence and development of IBD . We plan to express Catalase ( CAT ) , superoxide dismutase ( SOD ) and Elafin ( an endogenous human protein that inhibits neutrophil-derived serine proteases elastase and protease-3 ) in probiotics Escherichia coli Nissle 1917 . ...

UGM-Indonesia

October 21, 2023

colorectal-cancer-screening, escherichia-coli-nissle-1917, loop-initiated-rna-activator

diagnostics

UGM-Indonesia # Novel Biodevice for Colorectal Cancer Screening using Escherichia coli Nissle 1917 with miRNAs as Biomarker # Colorectal Cancer (CRC) screening is still difficult to access in rural areas even though early screening significantly reduces cancer mortality. We developed a novel screening method by utilizing Loop-Initiated RNA Activator (LIRA) OR Gate system to detect miR-21 and/or miR-92a as early biomarkers of CRC assembled within endogenous pMUT1 plasmid that were engineered into Escherichia coli Nissle 1917 (EcN) probiotic chassis. ...