engineered-pseudomonas-aeruginosa

SUSTech-MED

October 21, 2023
engineered-pseudomonas-aeruginosa, biofilm-targeted-therapy, c-di-gmp-pathway
therapeutics

SUSTech-MED # Engineered Pseudomonas aeruginosa filamentous phages for biofilm-targeted therapy # We aim to treat P. aeruginosa biofilms by editing a temperate bacteriophage with genes that affect the c-di-GMP pathway and quorum sensing. P. aeruginosa is a common and dangerous pathogen that forms biofilms, which are resistant to antibiotics and regulated by c-di-GMP and AHLs. We inserted wspF, yhjH, aiiA, and ytnP into the pf4 sequence of PAO1, and verified their effects on biofilm formation. ...