October 21, 2023
BNUZH-China # FeFighterS – Engineered Bacteria Induce Ferroptosis in Tumor Cells # In this project, we have developed a novel strategy that utilizes attenuated Salmonella typhimurium VNP20009 to induce ferroptosis in tumor cells. To further enhance the tumor targeting ability, we had genetically modified VNP20009 to express single chain antibody fragments on the outer membrane. Once the engineered bacteria reached the tumor tissue, it will secrete glucose oxidase into the tumor cells, mediating the occurrence of the Fenton reaction.
...
October 21, 2023
Guangxi-U-China # Engineered Bacteria with Nano-Immunomodulator for Precision Therapy of Triple Negative Breast Cancer # Triple negative breast cancer is the most aggressive subtype with poor prognosis and high risk of recurrence. The treatment is challenging because of limited chemotherapy responses, lack of actionable targets and acquired resistance to immune checkpoint inhibitors-based therapies. In particular, the acidic and hypoxic microenvironment caused by the high glycolytic activity of tumor cells promotes the non-inflammatory polarization of tumor-associated macrophages.
...
October 21, 2023
HiZJU-China # Biolens # Our project is dedicated to the prevention of myopia. The name of our project is biolens. We plan to load the modified engineered bacteria with contact lenses. The modified engineered bacteria can produce salidroside under the condition of elevated intraocular pressure, which is a biological antioxidant and has the function of preventing myopia. In addition, we designed the engineered bacteria to be coated with liposomal vesicles embedded with specific transporters to prevent metabolic waste from being excreted and allow only salidroside to pass through.
...
October 21, 2023
NJMU-China # Breaking the silence of the deep sea: One encounter at 52Hz frequency # Autism spectrum disorder (ASD) is a common neurodevelopmental disorder, and its incidence is increasing in recent years, which brings great burden to social development and medical security. It has been reported that due to genetic and environmental factors, the increased autoimmune antibodies in the brain of ASD patients will attack neurons, resulting in neuron death and disorder of behavior.
...
October 21, 2023
SHSID-China # E. cool-i: Temperature-based Kill Switch For Engineered Bacteria # Our team, E. cool-i, designed and developed a plasmid kill switch test kit based on temperature to control the growth of engineering bacteria and limit environmental pollution. We conducted surveys and interviewed experts working within the field of bioengineering to understand the impact of our product. Lastly, our team set out to educate the public about microbes through offline lectures, articles, comics, and games.
...
October 21, 2023
ZJUintl-China # Cancer Sniper: A new Lung Cancer Therapy # The Cancer Sniper is a new cancer Therapy based on engineered bacteria. We found a bacteria suitable for survival and secretion of anti-tumor factors in the lung cancer microenvironment by machine learning. Then we used 3 input AND gate which can simulate tumor microenvironment to trigger the expression of anti-tumor factor CDD-iRGD.We detected the expression of the anti-tumor factor and the anti-tumor efficiency of the bacteria.
...