Shanghai-HS

October 21, 2023

Shanghai-HS # Development of an optogenetics tool to accelerate CRY2/CIB1 switch off process for diabetes treatment # Diabetes, a prevalent endocrine disorder, is characterized by impaired insulin release and sustained high blood sugar levels. Optogenetic tools, such as the blue-light dependent CRY2/CIB1 switch, have shown promise in disease treatment, enabling noninvasive control of biological processes with precise spatiotemporal resolution. In this study, we combined UVR8, a UVB receptor found in plants, with the recently discovered blue-light inhibitors of cryptochromes BIC2 to create the UVR8N-BIC2 fusion protein. ...