clostridium-butyricum

NCSU

October 21, 2023
alzheimer's-disease, clostridium-butyricum, quantum-machine-learning
therapeutics

NCSU # Project Forget-Me-Not: A comprehensive study of Alzheimer’s disease # Alzheimer’s disease (AD) is a debilitating neurodegenerative disorder affecting over 55 million people worldwide. Currently no effective treatments exist to halt or reverse AD progression. This project develops a novel biotherapeutic to delay AD onset by engineering the probiotic bacterium Clostridium butyricum to produce the neuroprotective metabolite butyrate. Using a two-plasmid CRISPR/Cas9 gene editing system delivered via bacterial spores to the gut, C. ...