chimeric-antigen-receptor

Duke

October 21, 2023
chimeric-antigen-receptor, solid-tumors, gene-circuit
therapeutics

Duke # ICARUS - Intelligent Chimeric Antigen Upregulation System # Chimeric antigen receptor (CAR) T-cell therapy has shown great promise in treating certain hematologic cancers by reprogramming patient T-cells to target tumor antigens. However, application of this therapy to solid tumors has been limited by issues such as heterogeneity of antigen expression, tumor inaccessibility, and immunosuppressive tumor microenvironments. Our project describes an integrated CAR-synNotch circuit, the Intelligent Chimeric Antigen Receptor Upregulation System (ICARUS), to address these limitations. ...