Patras-Med

October 21, 2023

Patras-Med # Project ‘’Herophilus’’: breaking the barriers against pancreatic cancer. # Pancreatic cancer is one of the few cancers for which survival has not substantially improved over the last 25 years. Nowadays, Chimeric Antigen Receptor Therapy (CAR Therapy) has entered clinical practice. It is characterized as “living therapy” and CAR Natural Killer (CAR-NK) cells as “living drugs.” We aim to construct CAR-NK cells derived from induced Pluripotent Stem Cells (iPSCs) through second-generation lentiviral plasmids to bind specifically to Mesothelin (MSLN), a GPI-anchored protein on the membrane of pancreatic cancer cells, inducing immune response. ...