car-ma-immunotherapy

HKU-HongKong

October 21, 2023
car-ma-immunotherapy, tumour-associated-macrophages, sirp-alpha-knockout
therapeutics

HKU-HongKong # Car-Ma # Immunotherapy has been gaining popularity, and examples like CAR-T have been proven efficient in treating liquid cancer. However, in solid tumours, the tumour microenvironment (TME) acts as a physical barrier and prevents phagocytosis. Moreover, M2-like phenotype tumour-associated macrophages (TAMs) in TME would promote tumour growth. Our lab is working on delivering the CAR transgene into the tumour-associated macrophages that target hepatocellular carcinoma. First, we will be knocking out SIRP-alpha through the use of Cas9 gene editing, which enhances phagocytosis. ...