October 21, 2023
HUBU-HUBEI-CHINA # Seed Player: Metabolic Engineering of B. licheniformis For Enhanced Hydroxytyrosol Production # Hydroxytyrosol (HT) is a polyphenol found in olives, known for its antioxidant and anti-inflammatory properties. However, its large-scale application is limited due to the high production costs associated with traditional plant extraction and chemical synthesis methods. Microbial production offers a promising alternative but faces challenges such as low strain tolerance, complex synthesis pathways, and oxidative degradation.
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October 21, 2023
RUBochum # Breaking β-Lactams - Biosensors for Antibiotics # Multidrug-resistant bacteria are one of the major threats to humans nowadays. These pathogens can result from misuse, overuse and improper disposal of antibiotics and can lead to higher health care costs, longer disease progression and higher mortality. To prevent the emergence of multiple antibiotic resistances, antibiotics must be detected and deactivated. Since beta-lactam antibiotics are among the most used antibiotics, we aim to detect them.
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October 21, 2023
UConn # Degradation of 17α-ethynylestradiol by Genetically Engineering the CotA Laccase Gene of Bacillus licheniformis # The synthetic estrogen hormone 17α-ethynylestradiol (EE2) is a common degradation-resistant pharmaceutical that causes fertility disruption in aquatic organisms. EE2 enters waterways through sewage effluent and run-off from livestock activities. Wastewater treatment facilities provide an important role in reducing EE2, however, the degradation process is often incomplete. We aimed to design a bacterium that can more completely degrade EE2 in the wastewater treatment system.
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